Dereck Chisora (32-12, 23 KOs) will fight Kubrat Pulev on July 9 at The O2 Arena, London.
The two heavyweights renew hostilities for a second time in their careers having fought in 2016.
Their first fight which took place in Hamburg had been for the vacant European Heavyweight title when Chisora had old friend Tyson Fury cheering him on from ringside.
Pulev (29-2, 14 KOs) emerged victorious with a split decision win and dented Chisora’s hopes of challenging Anthony Joshua for the world title at that time.
Poland’s Adam Kownacki had been heavily linked to fighting ‘Del Boy’ but instead the big Bulgarian, a two-time challenger for the biggest prize in boxing, got the nod instead.
I’m delighted to get this fight over the line,” said Matchroom Sport Chairman Eddie Hearn.
“Initially we worked on some other opponents for Derek, but this fight came out of nowhere a few days ago and I absolutely love it! I think the strapline, ‘Total Carnage’, is absolutely perfect for this fight, in terms of the build-up and in terms of the fight itself.
“Expect the unexpected but expect a thriller at The O2 on July 9. Both men have been longstanding fixtures of the World Heavyweight division and it’s all or nothing at The O2 for both, as defeat could lead to the end of the road. Fans can expect a huge undercard and a brilliant main event for another brilliant event live on DAZN.”
Chisora is coming off back-to-back losses to Joseph Parker while Pulev gained 10-round points win against Jerry Forrest last time out.